Maciej Juryńczyk, MD, PhD
Principal Investigator

About me:

I am a neurologist and clinical scientist interested in multiple sclerosis, neuromyelitis optica and other inflammatory demyelinating diseases of the CNS. I have completed my neurology training and PhD thesis in the Department of Neurology at the Medical University of Lodz. I was subsequently a postdoctoral research fellow in the Nuffield Department of Clinical Neurosciences at the University of Oxford where I was involved in pioneer studies aimed at clinical, radiological and metabolomic characterisation of CNS demyelinating diseases, including a newly recognised condition associated with autoantibodies against myelin oligodendrocyte glycoprotein. I was also a Neurology Consultant with a special interest in multiple sclerosis in Hampshire and London Hospitals. Having obtained funding from the NAWA Polish Returns programme I have relocated to Poland and am now leading a research group in the Laboratory of Brain Imaging at the Nencki Institute of Experimental Biology in Warsaw.

Research interests:

My current research is aimed at optimising MR imaging methods to allow for accurate diagnosis of patients with atypical forms of CNS demyelination and combined features of multiple sclerosis and neuromyelitis optica.

Selected publications:

Juryńczyk M, Messina S, Palace J. Spinal cord and brain MRI should be
routinely performed during follow-up in patients with NMOSD - No. Mult Scler.
2021 Jan;27(1):15-16.
https://pubmed.ncbi.nlm.nih.gov/33141633/

Geraldes R, Juryńczyk M, Dos Passos GR, Pichler A, Chung K, Hagens M,
Ruggieri S, Auger C, Sastre-Garriga J, Enzinger C, Chard D, Barkhof F, Gasperini
C, Rovira A, DeLuca G, Palace J; MAGNIMS study group. The role of pontine lesion
location in differentiating multiple sclerosis from vascular risk factor-related
small vessel disease. Mult Scler. 2020 Aug 6
https://pubmed.ncbi.nlm.nih.gov/32757905/

Geraldes R, Juryńczyk M, Dos Passos G, Prichler A, Chung K, Hagens M, Ruggieri
S, Huerga E, Sastre-Garriga S, Enzinger C, Chard DT, Barkhof F, Gasperini
C, Rovira A, DeLuca GC, Palace J, MAGNIMS study group. Distinct Influence of
Different Vascular Risk Factors on White Matter Brain Lesions in Multiple Sclerosis. J
Neurol Neurosurg Psychiatry. 2020, 91:388.
https://pubmed.ncbi.nlm.nih.gov/32034114/

Juryńczyk M, Jacob A, Fujihara K, Palace J. Myelin oligodendrocyte glycoprotein
(MOG) antibody-associated disease: practical considerations. Pract Neurol. 2019;
19:187-195.
https://pubmed.ncbi.nlm.nih.gov/30530724/

Juryńczyk M, Probert F, Yeo T, Tackley G, Claridge TDW, Cavey A, Woodhall MR,
Arora S, Winkler T, Schiffer E, Vincent A, DeLuca G, Sibson NR, Isabel Leite M,
Waters P, Anthony DC, Palace J. Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease. Acta Neuropathol Commun. 2017; 5:95.
https://pubmed.ncbi.nlm.nih.gov/29208041/

Juryńczyk M, Messina S, Woodhall MR, Raza N, Everett R, Roca-Fernandez A,
Tackley G, Hamid S, Sheard A, Reynolds G, Chandratre S, Hemingway C, Jacob A,
Vincent A, Leite MI, Waters P, Palace J. Clinical presentation and prognosis in
MOG-antibody disease: a UK study. Brain. 2017; 140:3128-3138.
https://pubmed.ncbi.nlm.nih.gov/29136091/

Juryńczyk M, Geraldes R, Probert F, Woodhall M, Waters P, Tackley G, DeLuca
Gabriele, Chandratre S, Leite MI, Vincent A, Palace J. Distinct brain imaging
characteristics of autoantibody-mediated CNS conditions and multiple sclerosis.
Brain 2017; 140:617-627.
https://pubmed.ncbi.nlm.nih.gov/28364548/

Juryńczyk M, Tackley G, Kong Y, Geraldes R, Matthews L, Woodhall M, Waters P,
Kuker W, Craner M, Weir A, DeLuca GC, Kremer S, Leite MI, Vincent A, Jacob A, de
Sèze J, Palace J. Brain lesion distribution criteria distinguish MS from
AQP4-antibody NMOSD and MOG-antibody disease. J Neurol Neurosurg Psychiatry.
2017; 88:132-136.
https://pubmed.ncbi.nlm.nih.gov/27951522/

Juryńczyk M, Weinshenker B, Akman-Demir G, Asgari N, Barnes D, Boggild M,
Chaudhuri A, D'hooghe M, Evangelou N, Geraldes R, Illes Z, Jacob A, Kim HJ,
Kleiter I, Levy M, Marignier R, McGuigan C, Murray K, Nakashima I, Pandit L, Paul
F, Pittock S, Selmaj K, de Sèze J, Siva A, Tanasescu R, Vukusic S, Wingerchuk D,
Wren D, Leite I, Palace J. Status of diagnostic approaches to AQP4-IgG
seronegative NMO and NMO/MS overlap syndromes. J Neurol. 2016; 263:140-9.
https://pubmed.ncbi.nlm.nih.gov/26530512/

Juryńczyk M, Craner M, Palace J. Overlapping CNS inflammatory diseases:
differentiating features of NMO and MS. J Neurol Neurosurg Psychiatry. 2015;86:20-5.
https://pubmed.ncbi.nlm.nih.gov/25248365/

Funding:

Polish Returns programme of the Polish National Agency for Academic Exchange